Research Focus
LESA research for the management of control systems for circadian rhythm regulation in the treatment of sleep disorders and disruption in patients with traumatic brain injuries is supported by the Drosophila testbed at RPI. LESA researchers and industry members also have access to the inpatient Lighting Testbed at the University of New Mexico Hospital and the ICU Hospital Testbed at Thomas Jefferson University in Philadelphia. Both testbeds are equipped with an integrated network of tunable LED luminaires, sensors and controls designed to simulate the appropriate environment for human health lighting applications.
LESA research is also exploring the use of Time of Flight (ToF) sensors and technology platforms in the healthcare setting to provide powerful and discreet surveillance in environments where cameras would be ineffective, costly, or invasive.
Tools & Applications
- Circadian Rhythm Regulation
- Light-Based Therapeutics
- Patient Recovery
- Jet Lag Management
- Shift Worker Productivity
- Eldercare and Wellbeing
- Discrete Patient Monitoring
- Privacy Preserving Occupancy Tacking
Research Leads
- John Wen, RPI (Lead, Health & Welbeing)
- George Brainard, TJU
- Agung Julius, RPI
- Rich Radke, RPI (Lead, Occupancy Sensing)
- Arunas Tuzikas, RPI
Our Sponsors & Partners
Lead Institution
Rensselaer Polytechnic Institute
Core Research Partners
Boston University
The University of New Mexico
Thomas Jefferson University
Educational Outreach Partners
Howard University
Morgan State University
Rose-Hulman Institute of Technology
Healthcare Publications
Coming soon
2017
A.A. Julius, J. Yin and J.T. Wen, “Time Optimal Control for Circadian Entrainment for a Model with Circadian
and Sleep Dynamics”, in Proc. IEEE Conf. Decision and Control, Melbourne, Australia, pp. 4709 – 4714,
(2017).
J. Gleason, A.P. Vinod and M.M.K. Oishi, “Underapproximation of reach-avoid sets for discrete-time
stochastic systems via Lagrangian methods”, IEEE Conference on Decision and Control, Melbourne,
Australia, pp. 4283-4290, (2017).
J. Wen and S. Mishra, “Intelligent Building Control Systems”, Springer Nature Publishing, (2017).
M.H.T. Imam, S. Afshari and S. Mishra, “Autonomous Lighting Systems”, in Book: Intelligent Building
Control Systems, Springer, (2017).
G.C. Brainard, and J.P. Hanifin “Photoreception For Human Circadian, Neuroendocrine And
Neurobehavioral Regulation,” Handbook of Advanced Lighting Technology (R. Karlicek, C.-C. Sun, G. Zissis
and R. Ma, eds.) Springer-Verlag, Berlin. (2017)
2016
J. Gleason, A. Vinod, M. Oishi and R.S. Erwin, “Viable Set Approximation for Linear-Gaussian Systems with
Unknown, Bounded Variance“, IEEE 55th Conference on Conference on Decision and Control, (December
2016).
G.C.Brainard, L.K.Barger, R.R.Soler, and J.P.Hanifin, “The Development Of Lighting Countermeasures For
Sleep Disruption And Circadian Misalignment During Spaceflight,” Curr Opin Pulm Med, 22(6):535-544,
(November 2016).
A. Julius, J. Zhang, W. Qiao, J.T. Wen, “Multi-Input Adaptive Notch Filter And Observer For Circadian Phase
Estimation,” International Journal of Adaptive Control and Signal Processing, 30 (8–10), pp.1375–1388.
(Aug–Oct, 2016).
D. Roeper, J. Chen, J. Konrad, and P. Ishwar, “Privacy-Preserving, Indoor Occupant Localization Using a
Network of Single-Pixel Sensors”, in Proc. IEEE Int. Conf. Advanced Video and Signal-Based Surveillance
(AVSS), Colorado Springs, CO, 24-26, (August 2016).
C. Okaeme, S. Mishra, J.T. Wen, “A Comfort Zone Set-Based Approach For Coupled Temperature And
Humidity Control in Buildings,” IEE CASE, Dallas, TX, (Aug 2016).
J. Zhang, W. Qiao, J.T. Wen, and A. Julius, “Light-Based Circadian Rhythm Control: Entrainment And
Optimization,” Automatica, 68, pp. 44-55, (June, 2016).
Z. Yang, D.T. Pollock, J.T. Wen, “Model Predictive Control Of Vapor Compression Cycle For Large Transient
Heat Flux Cooling,” American Control Conference, Boston, MA, (July 2016).
D.T. Pollock, Z. Yang, J.T. Wen, “Charge Management For Large Transient Loads In A Multi-Evaporator
Vapor Compression System With Recuperator,” Intersociety Conference on Thermal and
Thermomechanical Phenomena in Electronic Systems (ITherm), Las Vegas, (May 2016).
I. Bhattacharya and R.J. Radke, “Arrays of Single Pixel Time-of-Flight Sensors for Privacy Preserving
Tracking and Coarse Pose Estimation,” Winter Conference on Applications of Computer Vision 2016,
(March 2016).
J. Chen, J. Wu, K. Richter, J. Konrad, and P. Ishwar, “Estimating Head Pose Orientation Using Extremely
Low Resolution Images,” Proc. IEEE Southwest Symposium on Image Analysis and Interpretation (SSIAI),
Santa Fe, NM, (Mar 2016).
R.T. Dauchy, M.A. Wren-Dail, A.E. Hoffman, J.P. Hanifin, B. Warfield, G.C. Brainard, S.M. Hill, V.P. Belancio,
E.M. Dauchy and D.E. Blask, “Effects Of Daytime Exposure To Light From Blue-Enriched Light-Emitting
Diodes On The Nighttime Melatonin Amplitude And Circadian Regulation Of Rodent Metabolism And
Physiology,” Comparative Medicine, 66(5):373-383, (2016).
L. Lu, J.T. Wen, “Human-Directed Coordinated Control Of Assistive Mobile Manipulator,” International
Journal of Intelligent Robotics and Applications, (2016).
J.X. Zhang, W. Qiao, J.T. Wen, A.A. Julius, “Light-Based Circadian Rhythm Control: Entrainment and
Optimization,” Automatica, Vol. 68, pp. 44-55, (2016).
A. Julius, J. Zhang, W. Qiao, and J.T. Wen, “Multi-Input Adaptive Notch Filter And Observer For Circadian
Phase Estimation,” Int. J. Adapt. Control Signal Process, (2016).
S. Gupta, K. Kar, S. Mishra, J.T. Wen, “BEES: Real-Time Occupant Feed-Back And Environmental Learning
Framework For Collaborative Thermal Management In Multi-Zone, Multi-Occupant Buildings,” Energy &
Buildings, 125, pp. 142-152. (2016).
T. K. Woodstock, R. J. Radke and A. C. Sanderson, “Sensor fusion for occupancy detection and activity
recognition using time-of-flight sensors“, 2016 19th International Conference on Information Fusion
(FUSION), Heidelberg, pp. 1695-1701, (2016).
2015
D.T. Pollock, Z. Yang, and J.T. Wen, “Dryout Avoidance Control For Multi-Evaporator Vapor Compression
Cycle Cooling,” Applied Energy, pp. 266-285, (December 2015).
J. Dai, J. Wu, B. Saghafi, J. Konrad, P. Ishwar, “Towards Privacy-Preserving Activity Recognition Using
Extremely Low Temporal and Spatial Resolution Cameras,” IEEE Workshop on Analysis and Modeling of
Faces and Gestures, CVPR, Boston, MA, (June 2015).
Z. Yang, D.T. Pollock, J.T. Wen, “Gain-Scheduling Control of Vapor Compression Cycle for Transient Heat-
Flux Removal,” Control Engineering Practice, Vol 39, pp. 67-89, (June 2015).
R.T.Dauchy, A. E. Hoffman, M.A.Wren-Dail, J.P.Hanifin, B. Warfield, G.C.Brainard, et. al., “Daytime Blue
Light Enhances The Nighttime Circadian Melatonin Inhibition Of Human Prostate Cancer Growth”,
Comparative Medicine, Vol 65, No 6, pp.473-485, (2015).
R.T. Dauchy, M.A. Wren, E.M. Dauchy, A.E. Hoffman, J.P. Hanifin, B. Warfield, M.R. Jablonski, G.C.
Brainard, S.M. Hill, L. Mao, G.L. Dobek, L.M. Dupepe and D.E. Blask, “The influence of red light exposure
at night on circadian metabolism and physiology in sprague-dawley rats“, J Am Assoc Lab Anim Sci,
54(1):40-50, (2015).
2014
Z. Yang, D.T. Pollock and J.T. Wen, “Dryout Avoidance Control for Multi-Evaporator Vapor Compression
Cycles with Transient Heat-Flux”, ASME 2014 International Mechanical Engineering Congress & Exposition
(IMECE), Montreal, Quebec, CANADA, (November 14-20, 2014).
O. L. Perez, A. Liu, and M. Shur, “Affective Lighting Toolbox for Psycho-physiological Research in Lighting.
An Interdisciplinary Research Approach Linked to ISO/IEEE 11073 (X73)”, IES Annual Conference: A
confluence of Art and Science, Pittsburgh, PA, USA, (November 2-4, 2014.)
C.O. Acholo, K. A. Connor, and R.J. Radke, “A Lighting Metric for Quantitative Evaluation of Accent Lighting
Systems”, Proc. SPIE 9190, Thirteenth International Conference on Solid State Lighting, (Sept 25, 2014).
A.Liu, M. Sandipan and M. Shur, “LED Illuminant on the Ambient Light”, Proc. SPIE 9190, Thirteenth
International Conference on Solid State Lighting, 919004(, Sept 25, 2014).
S.K. Gupta, K. Kar, S. Mishra and J.T. Wen, “Building Temperature Control With Active Occupant
Feedback“, IFAC World Congress Vol. 19, pp. 851-856, Capetown, SOUTH AFRICA, (August 24-29, 2014).
Q. Wang, X. Zhang, M. Wang, K.L. Boyer. “Learning Room Occupancy Patterns from Sparsely Recovered
Light Transport Models“, 22nd International Conference on Pattern Recognition, Stockholm, Sweden, pp.
1987-1992, (Aug 24-28, 2014).
M. Minakais, S. Mishra, J.T. Wen, “Groundhog Day: Iterative Learning for Building Temperature Control“,
IEEE International Conference on Automation Science and Engineering (CASE), pp.948,953, Taipei, (Aug
18-22, 2014).
A. Cunningham, W. Keddy-Hector, U. Sinha, D. Whalen, D. Kruse, J. Braasch and J.T. Wen, “Jamster: A
Mobile Dual-Arm Assistive Robot with Jamboxx Control”, Conference on Automation Science and
Engineering (CASE), pp.509-514, Taipei, TAIWAN, (August 18-22, 2014).
Q. Wang, X. Zhang, K.L. Boyer, “OccupQ. Wang, Xinchi Zhang, K. Boyer, “3D Scene Estimation with
Perturbation-Modulated Light and Distributed Sensors”, 2014 IEEE Conference on Computer Vision and
Pattern Recognition Workshops, pp. 252-257, Columbus OH, USA, (Jun 23-28, 2014).
Q. Wang, X. Zhang, K.L. Boyer, “Occupancy distribution estimation for smart light delivery with
perturbation-modulated light sensing“, Journal of Solid State Lighting, Vol. 1, No. 1 (2014).
J. Tani, S. Mishra, J.T.Wen, “Identification of Fast-Rate Systems Using Slow-Rate Image Sensor
Measurements”, Mechatronics, IEEE/ASME Transactions on, Vol. 19(4), pp.1343-1351, (2014).
G.C. Brainard, and J.P. Hanifin, “Exploring the Power of Light: from Photons to Human Health”,
Proceedings of CIE 2014 Lighting Quality and Energy Efficiency, Vienna, AUSTRIA, x039:19-31, (2014).
D. deHaro, K.J. Kines, M. Sokolowski, R.T. Dauchy, V.A. Streva, S.M. Hill, J.P. Hanifin, G.C. Brainard, D.E.
Blask and V.P. Belancio, “Regulation of L1 expression and retrotransposition by melatonin and its receptor;
implications for cancer risk associated with light exposure at night“, Nucleic Acids Research, 42(12):7694-
7707 (2014).
R.G. Stevens, G.C. Brainard, D.E. Blask, S.W. Lockley and M.E. Motta, “Breast cancer and circadian
disruption from electric lighting in the modern world“, CA Cancer J Clin 64:207-218 (2014).
J.J. Rainey, A.M. Cheriyadat, R.J. Radke, J.S. Crumly, and D.B. Koch, “Estimating Contact Rates at a Mass
Gathering by Using Video Analysis: a Proof-of-Concept Project“, BMC Public Health, Vol. 14:1101, pp. 1-6,
(2014).
D.T. Pollock, Z. Yang, J.T. Wen, Y. Peles, M.K. Jensen, “Model-Based Control of Vapor Compression Cycles
Transient Heat-Flux Removal”, International Journal of Heat and Mass Transfer, Vol.77, pp.662–683,
(2014).
L. Jia and R.J. Radke, Using Time-of-Flight Measurements for Privacy-Preserving Tracking in a Smart Room.
IEEE Transactions on Industrial Informatics, appeared online (March 8, 2013). URL:
http://dx.doi.org/10.1109/TII.2013.2251892
M. G. Figueiro, S. Nonaka, M. Rea, “Daylight exposure has a positive carry-over effect on nighttime
performance and subjective sleepiness”, Lighting Research and Technology, 45 (4), (2013);
doi:10.1177/1477153513494956
2012
Z. Schilling, E. Frank, V. Magidson, J. Wason, J. Loncarek, K. Boyer, J.Wen, A. Khodjakov, “Predictive-focus
illumination for reducing photodamage in live-cell microscopy”, Journal of Microscopy, 246(2), p.160-167,
May, 2012.
2011
M.S. Rea, M.G. Figueiro, A. Bierman, R. Hamner, “Modeling the spectral sensitivity of the human circadian
system,” Lighting Research and Technology, 1-12 (published online 14 December 2011).
M. G. Figueiro, N. Z. Lesniak, and M.S. Rea, “Implications of controlled short-wavelength light exposure
for sleep in older adults”, BMC Research Notes, 2011; 4:334.
M. Cretich, A. Reddington, M. R. Monroe, M. Bagnati, F. Damin, L. Sola, M. S. Unlu, and M. Chiari, “Silicon
biochips for dual label-free and fluorescence detection: Application to protein microarray development”,
Biosensors and Bioelectronics, Vol. 26, No. 9, pp.3938-3943, 15 May 2011,
M. R. Monroe, A. Reddington, A. D. Collins, C. D. Laboda, M. Cretich, M. Chiari, F. F. Little, and M. S. Unlu,
“Multiplexed method to calibrate and quantitate fluorescence signal for allergen-specific IgE”, Analytical
Chemistry, November 2011
2010
M. G. Figueiro and M. S. Rea, “The Effects of Red and Blue Lights on Circadian Variations in Cortisol, Alpha
Amylase, and Melatonin”, International Journal of Endocrinology, 2010:829351. Epub (Jun 24, 2010).
A. Yanik, M. Huang, O. Kamohara, A. Artar, T. W. Giesbert, J. J. Connor and H. Altug, “An Optofluidic
Nanoplasmonic Biosensor for Direct Detection of Live Viruses from Biological Media”, Nano Letters Vol.
10, pp. 4962-4969 (2010).
M. S. Rea, M. G. Figueiro, A. Beirman, J. D. Bullough, “Circadian Light”, Journal of Circadian Rhythms, Vol.
8, Issue 2 (2010).
L. Qin, C. Shing, S. Sawyer, and P. S. Dutta “Enhanced Ultraviolet Sensitivity of Zinc Oxide Nanoparticle
Photoconductors by Surface Passivation”, Optical Materials, Vol. 33, pp. 359-362, (2010)
L. Qin, C. Shing, and S. Sawyer, “Metal-Semiconductor-Metal Ultraviolet Photodetectors Based on Zinc-
Oxide Colloidal Nanoparticles”, IEEE Electron Device Letters, Vol. 32, pp. 51-53, (2010).
L. Qin, C. Shing, and S. Sawyer, “Comparison of UV Optical Properties of ZnO Nanoparticles Dispersed in
Traditional Organic and Novel Bio-Molecular Solvents”, Physics Status Solidi (c), Vol. 7, pp. 2463-2466,
(2010).
G. G. Daaboul, R. S. Vedula, S. Ahn, C. Lopez, A. Reddington, E. Ozkumur, and M. S. Ünlü, “LED-Based
Interferometric Reflectance Imaging Sensor for Quantitative Dynamic Monitoring of Biomolecular
Interactions”, Biosensors and Bioelectronics, doi:10.1016/j.bios.2, (November 2010).
G. G. Daaboul, A. Yurt, X. Zhang, G. M. Hwang, B. B. Goldberg, and M. S. Ünlü, “High-Throughput Detection
and Sizing of Individual Low-Index Nanoparticles and Viruses for Pathogen Identification”, Nano Letters,
(October 2010).
R. S. Vedula, G. G. Daaboul, A. Reddington, E. Ozkumur, D. A. Bergstein, and M. S. Ünlü, “Self-Referencing
Substrates for Optical Interferometric Biosensors”, Journal of Modern Optics, Vol. 57, No. 16, 20, pp. 1564-
156, (September 2010).
M. Cretich, D. Breda, F. Damin, M. Borghi, L. Sola, M. S. Ünlü, S. E. Burastero, and M. Chiari, “Allergen
Microarrays on High-Sensitivity Silicon Slides”, Analytical and Bioanalytical Chemistry, (22 August 2010).
E. Ozkumur, C. Lopez, A. Yalcin, J. H. Connor, M. Chiari, and M. S. Ünlü, “Spectral Reflectance Imaging for
a Multiplexed, High-Throughput, Label-Free, and Dynamic Biosensing Platform”, IEEE Journal of Selected
Topics in Quantum Electronics, Vol. 16, No. 3, pp. 635-46, (May/June 2010).
E. Ozkumur, S. Ahn, A. Yalcin, C. Lopez, E. Cevik, R. Irani, C. DeLisi, M. Chiari, and M. S. Ünlü, “Label-Free
Microarray Imaging for Direct Detection of DNA Hybridization and Single-Nucleotide Mismatches,”
Biosensors and Bioelectronics, Vol. 25, No. 7, pp. 1789-1795, (2010).
2009
B. Potsaid, F. Finger, J.T. Wen, “Automation of Challenging Spatial-Temporal Biomedical Observations
with the Adaptive Scanning Optical Microscope (ASOM), “IEEE Transaction on Automation Science and
Engineering”, Vol 6, No 3, pp. 525-535, (2009).